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Regulatory Role of Quiescence in the Biological Function of Cancer Stem Cells.
Stem Cell Reviews and Reports ( IF 4.8 ) Pub Date : 2020-09-07 , DOI: 10.1007/s12015-020-10031-8
Sau Har Lee 1, 2 , Tamika Reed-Newman 3 , Shrikant Anant 3 , Thamil Selvee Ramasamy 1, 4
Affiliation  

Quiescence in cancer cells is considered a therapeutic challenge as it confers dormancy in tumour, hence circumventing inherent anti-neoplastic surveillance system and standard-of-care cancer therapeutics including chemotherapy and radiotherapy. Since majority of the therapeutics target actively proliferating cancer cells, cancer cells eventually develop quiescent nature as mechanism of survival and cancer progression under both niche and therapeutic pressures. Quiescence state in cancer cells, eventually, confers resistant and aggressive nature to conventional cancer therapies, resulting in disease progression and relapse. Therefore, targeting quiescent cancer cells or cancer stem cells is a promising therapeutic approach, however an extensive review of the relevant information is needed in order to device an effective therapy. While the evidence of quiescence regulation in CSCs is rather a complex molecular and cellular network, herein, we aim to provide a comprehensive understanding of both intrinsic and extrinsic regulation in association with the function of CSCs. Findings on induction of quiescent state in CSCs population, its regulation at both cellular and molecular level, key molecular regulators, cellular events and processes including potential targets to develop therapeutics are extensively reviewed. This review also highlights the impact of CSC plasticity on quiescence which capturing the key challenge of targeting the cells in this state. Beyond understanding the mechanisms underlying quiescence nature of cancer cells, this review provides insightful perspective and future direction on insight in targeting these populations, hence collapse the tumour dormancy programme in order to eradicate tumour mass as a whole.



中文翻译:

静止在癌症干细胞生物学功能中的调节作用。

癌细胞的静止被认为是一种治疗挑战,因为它使肿瘤处于休眠状态,因此绕过了固有的抗肿瘤监测系统和标准的癌症治疗方法,包括化疗和放疗。由于大多数疗法针对的是活跃增殖的癌细胞,因此癌细胞最终会在生态位和治疗压力下发展出作为生存和癌症进展机制的静止性质。癌细胞的静止状态最终赋予传统癌症疗法抵抗性和侵袭性,导致疾病进展和复发。因此,靶向静止的癌细胞或癌症干细胞是一种很有前景的治疗方法,但需要对相关信息进行广泛的审查,以制定有效的治疗方案。虽然 CSC 中静止调节的证据是相当复杂的分子和细胞网络,但在本文中,我们旨在全面了解与 CSC 功能相关的内在和外在调节。对 CSC 群体中静止状态的诱导、其在细胞和分子水平上的调节、关键分子调节剂、细胞事件和过程(包括开发治疗方法的潜在靶点)的发现进行了广泛审查。这篇综述还强调了 CSC 可塑性对静止的影响,它抓住了在这种状态下靶向细胞的关键挑战。除了了解癌细胞静止特性的潜在机制外,本综述还提供了洞察力的洞察力和未来方向,以洞察针对这些人群的洞察力,

更新日期:2020-09-08
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