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The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-09-07 , DOI: 10.1134/s1607672920040067 T A Gudasheva 1 , P Yu Povarnina 1 , K N Koliasnikova 1 , A G Alyaeva 1 , O N Vorontsova 1 , S B Seredenin 1
中文翻译：
神经肽环戊基甘氨酸的抗焦虑作用由AMPA和TrkB受体介导。
更新日期：2020-09-07
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-09-07 , DOI: 10.1134/s1607672920040067 T A Gudasheva 1 , P Yu Povarnina 1 , K N Koliasnikova 1 , A G Alyaeva 1 , O N Vorontsova 1 , S B Seredenin 1
Affiliation
Abstract
Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.中文翻译：
神经肽环戊基甘氨酸的抗焦虑作用由AMPA和TrkB受体介导。
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