Acute RNA viral encephalomyelitis is a serious complication of numerous virus infections. Antibodies in the cerebral spinal fluid (CSF) are correlated to better outcomes, and there is substantive evidence of antibody secreting cells (ASCs) entering the central nervous system (CNS) and contributing to resolution of infection. Here, we review the RNA viruses known to cause acute viral encephalomyelitis with mechanisms of control that require antibody or ASCs. We compile the cytokines, chemokines, and surface receptors associated with ASC recruitment to the CNS after infection and compare known antibody-mediated mechanisms as well as potential noncytolytic mechanisms for virus control. These non-canonical functions of antibodies may be employed in the CNS to protect precious non-renewable neurons. Understanding the immune-specialized zone of the CNS is essential for the development of effective treatments for acute encephalomyelitis caused by RNA viruses.

中文翻译：

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急性RNA病毒性脑脊髓炎及其在中枢神经系统中的作用。

急性RNA病毒性脑脊髓炎是许多病毒感染的严重并发症。脑脊髓液（CSF）中的抗体与更好的预后相关，并且有大量证据表明抗体分泌细胞（ASC）进入中枢神经系统（CNS）并有助于解决感染。在这里，我们回顾了已知引起急性病毒性脑脊髓炎的RNA病毒，其控制机制需要抗体或ASC。我们将与感染后ASC募集到CNS的细胞因子，趋化因子和表面受体相关联，并比较已知的抗体介导的机制以及潜在的非溶细胞性病毒控制机制。抗体的这些非规范功能可用于CNS中，以保护珍贵的不可再生神经元。