Emerging oncotherapeutic strategies require the induction of an immunostimulatory tumor microenvironment (TME) containing numerous tumor‐reactive CD8⁺ T cells. Interleukin‐7 (IL‐7), a T‐cell homeostatic cytokine, induces an antitumor response; however, the detailed mechanisms underlying the contributions of the IL‐7 to TME remain unclear. Here, we aimed to investigate the mechanism underlying the induction of antitumor response by hybrid Fc‐fused long‐acting recombinant human IL‐7 (rhIL‐7‐hyFc) through regulation of both adaptive and innate immune cells in the TME.

中文翻译：

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混合 Fc 融合的白细胞介素-7 诱导发炎的肿瘤微环境并提高癌症免疫治疗的疗效

^{新兴的肿瘤治疗策略需要诱导含有大量肿瘤反应性 CD8 +} T 细胞的免疫刺激性肿瘤微环境 (TME) 。白细胞介素-7 (IL-7) 是一种 T 细胞稳态细胞因子，可诱导抗肿瘤反应；然而，IL-7 对 TME 贡献的详细机制仍不清楚。在这里，我们旨在通过调节 TME 中的适应性和先天免疫细胞来研究混合 Fc 融合长效重组人 IL-7 (rhIL-7-hyFc) 诱导抗肿瘤反应的机制。