Hippocampal subfield pathologic burden in Lewy body diseases vs . Alzheimer’s disease,Neuropathology and Applied Neurobiology

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Hippocampal subfield pathologic burden in Lewy body diseases vs . Alzheimer’s disease
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2020-09-24 , DOI: 10.1111/nan.12659
D G Coughlin _{1,

2,

3} , R Ittyerah ₄ , C Peterson _{1,

2} , J S Phillips _{1,

2,

5} , S Miller ₁ , K Rascovsky _{2,

5} , D Weintraub _{2,

6,

7} , A D Siderowf _{2,

6} , J E Duda _{2,

6,

7} , H I Hurtig ₂ , D A Wolk _{2,

8} , C T McMillan _{2,

5} , P A Yushkevich ₄ , M Grossman _{2,

5} , E B Lee _{9,

10} , J Q Trojanowski _{9,

10} , D J Irwin _{1,

2,

5,

6}

Affiliation

Penn Digital Neuropathology Laboratory at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Neurology at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Neurosciences, University California San Diego, San Diego, CA, USA.
Department of Radiology at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Frontotemporal Dementia Center at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
LBDA Research Center of Excellence at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Michael J. Crescenz VA Medical Center, Parkinson's Disease Research, Education, and Clinical Center, Philadelphia, PA, USA.
Alzheimer's disease Research Center at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Pathology at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Center for Neurodegenerative Disease Research at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Lewy body diseases (LBD) are characterized by alpha‐synuclein (SYN) pathology, but comorbid Alzheimer’s disease (AD) pathology is common and the relationship between these pathologies in microanatomic hippocampal subfields is understudied. Here we use digital histological methods to test the association between hippocampal SYN pathology and the distribution of tau and amyloid‐beta (Aβ) pathology in LBD and contrast with AD subjects. We also correlate pathologic burden with antemortem episodic memory testing.

中文翻译：

路易体病的海马亚区病理负担与 . 阿尔茨海默氏病

路易体病 (LBD) 的特征是 α-突触核蛋白 (SYN) 病理学，但合并阿尔茨海默病 (AD) 病理学很常见，并且这些病理学在微解剖海马亚区中的关系尚未得到充分研究。在这里，我们使用数字组织学方法来测试 LBD 中海马 SYN 病理学与 tau 和淀粉样蛋白-β (Aβ) 病理学分布之间的关联，并与 AD 受试者进行对比。我们还将病理负担与生前情景记忆测试相关联。

更新日期：2020-09-24

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