MiR‐98‐5p promotes ischemia/reperfusion‐induced microvascular dysfunction by targeting NGF and is a potential biomarker for microvascular reperfusion,Microcirculation

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MiR‐98‐5p promotes ischemia/reperfusion‐induced microvascular dysfunction by targeting NGF and is a potential biomarker for microvascular reperfusion
Microcirculation ( IF 2.4 ) Pub Date : 2020-09-06 , DOI: 10.1111/micc.12657
Yisen Hu ₁ , Jingjie Xiong ₁ , Hong Wen ₁ , Heng Wei ₁ , Xiaocong Zeng ₁

Affiliation

This study examined the correlation between serum miR‐98‐5p levels and indices of microvascular reperfusion in patients undergoing primary percutaneous coronary intervention (pPCI) after ST‐segment elevation myocardial infarction (STEMI). Additionally, we evaluated the mechanisms by which miR‐98‐5p promoted ischemia/reperfusion (I/R)‐induced injury in both cultured cell lines and an animal model.

中文翻译：

MiR-98-5p 通过靶向 NGF 促进缺血/再灌注诱导的微血管功能障碍，是微血管再灌注的潜在生物标志物

本研究探讨了 ST 段抬高型心肌梗死 (STEMI) 后接受原发性经皮冠状动脉介入治疗 (pPCI) 的患者血清 miR-98-5p 水平与微血管再灌注指数之间的相关性。此外，我们评估了 miR-98-5p 在培养细胞系和动物模型中促进缺血/再灌注 (I/R) 诱导的损伤的机制。

更新日期：2020-09-06

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