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Neuromedin U: potential roles in immunity and inflammation.
Immunology ( IF 6.4 ) Pub Date : 2020-09-05 , DOI: 10.1111/imm.13257
Yuan Ye 1, 2 , Zongan Liang 2 , Luzheng Xue 1
Affiliation  

Since the discovery of neuromedin U (NmU) from porcine spinal cord in 1985, this neuropeptide has been subsequently identified in many other species with multiple physiological and pathophysiological roles detected, ranging from smooth muscle contraction, feeding, energy balance to tumorigenesis. Intriguingly, NmU is also emerging to play pro‐inflammatory roles involving immune cell activation and cytokine release in a neuron‐dependent or neuron‐independent manner. The NmU‐mediated inflammatory responses have already been observed in worm infection, sepsis, autoimmune arthritis and allergic animal models. In this review, we focus on the roles of NmU in immunity and inflammation by highlighting the interactions between NmU and immune cells, summarizing the signalling mechanism involved in their reactions and discussing its potential contributions to inflammatory diseases.

中文翻译:

Neuromedin U:在免疫和炎症中的潜在作用。

自从 1985 年从猪脊髓中发现神经调节蛋白 U (NmU) 以来,随后在许多其他物种中发现了这种神经肽,这些物种具有多种生理和病理生理作用,范围从平滑肌收缩、进食、能量平衡到肿瘤发生。有趣的是,NmU 也开始以神经元依赖性或神经元非依赖性方式发挥促炎作用,涉及免疫细胞激活和细胞因子释放。已经在蠕虫感染、败血症、自身免疫性关节炎和过敏动物模型中观察到 NmU 介导的炎症反应。在这篇综述中,我们通过强调 NmU 和免疫细胞之间的相互作用来关注 NmU 在免疫和炎症中的作用,
更新日期:2020-09-05
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