Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2020-09-06 , DOI: 10.1016/j.bmcl.2020.127525 Qing Zhang 1 , Kuantao Zhao 1 , Lixun Zhang 1 , Xiaoyu Jiao 1 , Yongjie Zhang 1 , Chunlei Tang 1
As a class III receptor tyrosine kinase (RTK), FMS-like tyrosine kinase 3 (FLT3) is always overexpressed in many cases of acute leukemia. This paper studies the structure-based synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors. Encouragingly, compounds 15b, 16b, 24a, and 24c showed excellent biological activities in a low nanomolar range. In particular, compound 16b demonstrated significant inhibitory potency against FLT3-ITD (IC50 = 5.60 nM) and better antiproliferative activity than quizartinib against MV4-11 cell line (IC50 = 0.176 nM). It is indicated that compound 16b for the treatment of acute myeloid leukemia could be very promising.
中文翻译:
二芳基脲衍生物作为FLT3抑制剂的合成及生物学评价。
作为III类受体酪氨酸激酶(RTK),FMS样酪氨酸激酶3(FLT3)在许多急性白血病病例中总是过表达。本文研究了二芳基脲衍生物作为FLT3抑制剂的结构化合成和生物学评价。令人鼓舞的是,化合物15b,16b,24a和24c在低纳摩尔范围内显示出出色的生物活性。特别地,化合物16b表现出对FLT3-ITD的显着抑制作用(IC 50= 5.60nM),并且比奎扎替尼对MV4-11细胞系具有更好的抗增殖活性(IC 50=0.176nM )。表明化合物16b 对于急性髓细胞白血病的治疗可能非常有前途。