Hydration lubrication is the key responsible for the exceptionally low boundary friction between biosurfaces. However, it is a challenge to settle a hydration layer on a polymer surface via a noncovalent manner. Herein, we develop a highly lubricated coating absorbed onto the polymer surface via intermolecular association of hyaluronic acid (HA)-based micelles. A poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) triblock copolymer (Pluronic, F127) is recruited to complex with HA and further self-assembled to form a thick micelle layer. High water-retaining capacity of the HA/F127 coating enables the decorated surface with excellent hydrophilicity and boundary lubrication, where the coefficient of friction in aqueous media is reduced by 60% compared with the bare polymer surface. The HA/F127 coating suppresses nonspecific protein adsorption and exhibits good biocompatibility. More remarkably, an in vivo cynomolgus monkey model, demonstrates the utility of the HA/F127 coating in alleviating or preventing complications of endotracheal intubation, such as foreign irritation, airway mucosal damage, and inflammatory response. This cost-effective and scalable approach is suitable to manufacture interventional devices especially disposable medical devices with highly lubricated surface.

水合润滑是生物表面之间异常低的边界摩擦的关键。然而，通过非共价方式将水合层沉积在聚合物表面上是一个挑战。在本文中，我们开发了一种透明质酸涂层，可通过透明质酸（HA）基胶束的分子间缔合而吸收到聚合物表面上。招募聚（环氧乙烷）-b-聚（环氧丙烷）-b-聚（环氧乙烷）三嵌段共聚物（Pluronic，F127）与HA络合，并进一步自组装以形成厚的胶束层。HA / F127涂层的高保水能力使装饰表面具有出色的亲水性和边界润滑性，与裸露的聚合物表面相比，水性介质中的摩擦系数降低了60％。HA / F127涂层可抑制非特异性蛋白质的吸附，并具有良好的生物相容性。更值得注意的是体内食蟹猴模型证明了HA / F127涂层在缓解或预防气管插管并发症（如外来刺激，气道粘膜损伤和炎症反应）方面的实用性。这种经济高效且可扩展的方法适用于制造介入设备，特别是具有高度润滑表面的一次性医疗设备。