The pathophysiology of transient global amnesia (TGA) is still uncertain. In the province of Ferrara (Fe-province), Italy, given the health organization and the alarming clinical features, the cases of TGA in the resident population virtually correspond to the resident outpatients diagnosed as TGA cases in the ER of the University Hospital of Ferrara. Thanks to this, a retrospective survey identified 35 (14 men, 21 women) first-ever TGA cases in the resident population in 2018 (346,975 inhabitants) giving a crude incidence rate of 10.10/100,000 (95% CI 7.00–14.00), 8.40/100,000 (95% CI 4.60–14.10) for men, and 11.60/100,000 (95% CI 7.20–17.80) for women, a non-significant gender difference. The incident cases of TGA were evenly distributed according to both season and month. The monthly cases of TGA followed the Poisson distribution (goodness-of-fit test: λ = 2.9, χ² = 2.557, 5 degrees of freedom, p > 0.70). The incidence of TGA in the Fe-province was higher in the highest level of urbanization (21.40/100,000 95% CI 13.10–33.00) than in the lowest one (4.20/100,000 95% CI 1.92–8.00). The incident cases of TGA increased with the level of urbanization (χ² trend test = 19.940, p < 0.001) and the population density (inhabitants/km²) level (χ² trend test = 46.684, p < 0.001). Since urbanization is likely involved in stress-related disorders, these findings achieved in a well-defined homogeneous population seem to support the hypothesis of the involvement of stress, maybe in vulnerable individuals, in TGA.

暂时性全球性健忘症（TGA）的病理生理学仍不确定。在意大利费拉拉省（Fe-province），鉴于卫生组织和令人震惊的临床特征，常住人口中的TGA病例实际上对应于费拉拉大学医院急诊室中被诊断为TGA病例的住院病人。因此，一项回顾性调查确定了2018年常住人口中有35例（14例男性，21例女性）首次TGA病例（346,975居民），粗发病率分别为10.10 / 100,000（95％CI 7.00-14.00），8.40男性为/ 100,000（95％CI 4.60–14.10），女性为11.60 / 100,000（95％CI 7.20–17.80），性别差异不显着。TGA的事件病例按季节和月份平均分配。²  = 2.557，5个​​自由度，p  > 0.70）。在铁省，城市化水平最高的地区（21.40 / 100,000 95％CI 13.10-33.00）的TGA发病率高于最低的地区（4.20 / 100,000 95％CI 1.92-8.00）。TGA的入射例城市化水平增加（χ ²趋势检验= 19.940，p  <0.001）和人口密度（居民/千米²）级（χ ²趋势检验= 46.684，p  <0.001）。由于城市化可能与压力相关的疾病有关，因此在明确定义的同质人群中获得的这些发现似乎支持了TGA中可能涉及压力的假设，可能是弱势群体。