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Synthesis of copper-silver doped hydroxyapatite via ultrasonic coupled sol-gel techniques: structural and antibacterial studies
Journal of Sol-Gel Science and Technology ( IF 2.5 ) Pub Date : 2020-09-06 , DOI: 10.1007/s10971-020-05407-8
S. Kamonwannasit , C. M. Futalan , P. Khemthong , T. Butburee , A. Karaphun , P. Phatai

Fabrication of hydroxyapatite (HA) via doping with metal ions to enhance its antibacterial properties has attracted much interest. The present study aims to synthesize copper-silver doped hydroxyapatite particles (Cu-Ag doped HA) with an improved antibacterial activity through a sol-gel technique coupled with ultrasonic irradiation. The doping materials consist of Cu2+ and Ag+ ions with precursor molar ratios of 0.0, 0.25, 0.50, 0.75 and 1.0. The physicochemical properties of Ca9.0Cu1.0-xAgx(PO4)6(OH)2 samples were investigated using X-ray diffraction, Fourier-transform infrared spectroscopy (FT-IR), and transmission electron microscopy coupled with energy dispersive X-ray analysis (TEM-EDS). Characterization studies revealed that Cu2+ and Ag+ ions were incorporated into a hexagonal framework of HA. The main functional groups were identified as hydroxyl (OH) and phosphate (PO43−) moieties. Their morphologies were rod-shaped with various diameters and particle size distributions, depending on the molar ratio of Cu2+ to Ag+. Antibacterial activity was evaluated using an agar well diffusion method against Staphylococcus epidermis, S. aureus, Bacillus subtilis, B. cereus, and Pseudomonas aeruginosa. It was found that Cu-Ag doped HA is an effective antibacterial agent. Ca9.0Cu0.5Ag0.5(PO4)6(OH)2 showed the best antibacterial performance against all bacterial strains with inhibition zones ranging from 13 to 17 mm, indicating its suitability as an antibacterial material in biomedical applications.



中文翻译:

超声耦合溶胶-凝胶技术合成铜银掺杂羟基磷灰石:结构和抗菌研究

通过掺杂金属离子以增强其抗菌性能来制备羟基磷灰石(HA)引起了人们的极大兴趣。本研究旨在通过溶胶-凝胶技术结合超声辐射合成具有改善的抗菌活性的铜银掺杂羟基磷灰石颗粒(Cu-Ag掺杂HA)。掺杂材料由Cu 2+和Ag +离子组成,前体摩尔比为0.0、0.25、0.50、0.75和1.0。Ca 9.0 Cu 1.0-x Ag x(PO 46(OH)2的理化性质使用X射线衍射,傅立叶变换红外光谱(FT-IR)和透射电子显微镜结合能量色散X射线分析(TEM-EDS)对样品进行了研究。表征研究表明,Cu 2+和Ag +离子被掺入HA的六边形骨架中。主要的官能团被鉴定为羟基(OH - )和磷酸(PO 4 3-)的部分。它们的形态为棒状,具有各种直径和粒径分布,这取决于Cu 2+与Ag +的摩尔比。使用琼脂井扩散法评估对表皮葡萄球菌的抗菌活性,金黄色葡萄球菌枯草芽孢杆菌蜡状芽孢杆菌铜绿假单胞菌。发现Cu-Ag掺杂的HA是有效的抗菌剂。Ca 9.0 Cu 0.5 Ag 0.5(PO 46(OH)2对所有细菌均表现出最佳的抗菌性能,其抑制区范围为13至17 mm,这表明其在生物医学应用中作为抗菌材料的适用性。

更新日期:2020-09-07
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