In this study, we developed a convenient methodology for the N-arylation of various acetamides, benzamides and related compounds by iodoferrocene. Optimization of the reaction was first performed from acetamide on the basis of the achievements in the benzene series. Next, the identified conditions (use of copper(I) iodide, N,N′-dimethylethylenediamine, tripotassium phosphate in dioxane at 90 °C for 14 h) were applied to different aliphatic/aromatic primary and cyclic/acyclic secondary amides in order to determine the scope of the reaction, thus easily generating a small library of ferrocene amides.

中文翻译：

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碘二茂铁作为酰胺N-芳基化的伙伴

在这项研究中，我们开发了一个方便的方法ñ各种乙酰胺，苯酰胺和iodoferrocene相关化合物的-arylation。首先根据乙苯系列的成果，从乙酰胺进行反应的优化。接下来，将确定的条件（在二恶烷中于90°C下使用碘化铜（I），N，N'-二甲基乙二胺，磷酸三钾14小时）以用于不同的脂族/芳族伯酰胺和环状/无环仲酰胺。确定反应的范围，从而容易生成小的二茂铁酰胺库。