This study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR) spectroscopy were used to characterize the structures. Water uptake percentage and vancomycin release were also measured. The antibacterial activity against Staphylococcus aureus was investigated. According to the results, mean pore diameter (MPD) was decreased by addition of PEG and reached to 1.3 ± 0.5 μ m. On the other hand, 43% decrease in water content of the hydrogels showed along with the incorporation of PEG. The inhibition zone confirmed antibacterial effect of the vancomycin-loaded hydrogels. The porous CS/PVA/PEG hydrogels containing vancomycin could be good candidates to potentially be used as wound dressing.

中文翻译：

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载有万古霉素的壳聚糖/ PVA / PEG水凝胶的制备及表征

这项研究描述了一种用于递送万古霉素的载药多孔水凝胶。通过冻干制备基于壳聚糖（CS），聚乙烯醇（PVA）和聚乙二醇（PEG）的水凝胶。使用扫描电子显微镜（SEM），差示扫描量热法（DSC）和傅立叶变换红外（FTIR）光谱来表征结构。还测量了吸水率和万古霉素释放。研究了对金黄色葡萄球菌的抗菌活性。根据结果​​，平均孔径（MPD）通过添加PEG降低并达到1.3±0.5μm。另一方面，随着PEG的掺入，水凝胶的水含量降低了43％。抑制区证实了载有万古霉素的水凝胶的抗菌作用。