The use of metal oxide nanoparticles for the development of cost-effective glucose biosensors has been receiving increased attention. Enzymatic and non-enzymatic glucose sensor using polyethylene glycol (PEG) grafted manganese ferrite (PEG-MnFe 2 O 4 ) nanoparticles (NPs) modified onto a glassy carbon electrode (GCE) is reported in the present study. XRD and Raman studies confirmed the cubic spinel structure of MnFe 2 O 4. The immobilization of glucose oxidase (GOx) on PEG-MnFe 2 O 4 (GOx@PEG-MnFe 2 O 4 ) was validated using FTIR and TGA. Sensing electrodes exhibited well-defined redox peaks in 0.1 M phosphate buffered saline (PBS) solution at pH 7.4 against the reference electrode Ag/AgCl. GOx@PEG-MnFe 2 O 4 /GCE displayed a sensitivity of 1.985 μ A mM −1 cm −2 in the linear range of 1 to 20 mM with a limit of detection (LOD) of 0.132 mM whereas non-enzymatic se...

中文翻译：

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锰铁氧体纳米颗粒酶法和非酶法检测葡萄糖的比较研究

将金属氧化物纳米颗粒用于开发具有成本效益的葡萄糖生物传感器已受到越来越多的关注。本研究报告了使用修饰到玻璃碳电极（GCE）上的聚乙二醇（PEG）接枝锰铁氧体（PEG-MnFe 2 O 4）纳米粒子（NPs）进行酶和非酶葡萄糖传感器。XRD和拉曼研究证实了MnFe 2 O 4的立方尖晶石结构。使用FTIR和TGA验证了葡萄糖氧化酶（GOx）在PEG-MnFe 2 O 4（GOx @ PEG-MnFe 2 O 4）上的固定。感应电极在pH 7.4的0.1 M磷酸盐缓冲盐水（PBS）溶液中相对于参比电极Ag / AgCl表现出明确的氧化还原峰。GOx @ PEG-MnFe 2 O 4 / GCE在1至20 mM的线性范围内显示1.985μAmM -1 cm -2的灵敏度，检测限（LOD）为0。