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Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene
Clinical Phytoscience Pub Date : 2020-09-04 , DOI: 10.1186/s40816-020-00204-w
Damilola Alex Omoboyowa , Kayode Olayele Karigidi , Temitope Cosmas Aribigbola

Renal failure is among the main complications of diabetes disorders and free radical from hyperglycemia is the major cause of this nephrotic complication. This study investigated the therapeutic effects of Bridelia ferruginea Benth on nephrotic damage in streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by injection of 50 mg/kg b. w. of STZ (intraperitoneal) in rats fasted overnight. Effect on nephropathy was assessed using biochemical, histological indices and gene expression of kidney tissue. The total flavonoids and phenolic content of petroleum ether fraction of B. ferruginea (PEFBF) was observed to be higher compared to diethyl ether fraction of B. ferruginea (DEFBF). The 1,1-diphenyl-2-picryl-hydrazyl scavenging activity of the fractions were significantly (P < 0.05) reduced across the concentrations compared to the standard (gallic acid). The STZ-induced diabetic animals treated with 100 and 200 mg/kg b.w. of PEFBF and DEFBF showed significant (P < 0.05) reduction in blood glucose level on days 7, 11 and 14 compared to untreated diabetic rats. STZ-induced diabetic rats significantly (P < 0.05) exhibited increase plasma urea, creatinine, protein and albumin level while treatment with both fractions of B. ferruginea reduced the level of these parameters in treated diabetic rats. B. ferruginea also caused down-regulation of neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and cystatin c genes. These results revealed that, the plant has hypoglycemic activity therefore provides a pharmacological basis for its folkloric use in the management of hyperglycemia and its associated renal dysfunction.

中文翻译:

野菜花草叶通过靶向NGAL / KIM-1 /胱抑素c基因减轻STZ诱导的大鼠的糖尿病肾病

肾衰竭是糖尿病疾病的主要并发症之一,而来自高血糖症的自由基是这种肾病并发症的主要原因。这项研究调查了白花丹参对链脲佐菌素(STZ)诱导的糖尿病大鼠肾病损害的治疗作用。通过在禁食过夜的大鼠中注射50 mg / kg bw的STZ(腹膜内)来诱导糖尿病。使用生化,组织学指标和肾脏组织的基因表达评估对肾病的影响。观察到与B.ferruginea(DEFBF)的乙醚部分相比,B。ferruginea(PEFBF)的总类黄酮和酚含量更高。馏分的1,1-二苯基-2-吡啶基-肼基清除活性显着(P <0。05)与标准品(没食子酸)相比降低了整个浓度。与未治疗的糖尿病大鼠相比,用100和200 mg / kg bw的PEFBF和DEFBF治疗的STZ诱导的糖尿病动物在第7、11和14天的血糖水平显着降低(P <0.05)。STZ诱导的糖尿病大鼠的血浆尿素,肌酐,蛋白质和白蛋白水平显着升高(P <0.05),而用B. ferruginea的两种治疗均降低了这些糖尿病大鼠的这些参数水平。B. ferruginea还引起中性粒细胞明胶酶相关的脂蛋白,肾损伤分子1和cystatin c基因的下调。这些结果表明,
更新日期:2020-09-05
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