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Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder.
BMC Psychiatry ( IF 4.4 ) Pub Date : 2020-09-04 , DOI: 10.1186/s12888-020-02841-4
Sayo Hamatani 1, 2 , Aki Tsuchiyagaito 1, 3 , Masato Nihei 1 , Yuta Hayashi 4, 5 , Tokiko Yoshida 1 , Jumpei Takahashi 1 , Sho Okawa 5, 6 , Honami Arai 1 , Maki Nagaoka 1 , Kazuki Matsumoto 1 , Eiji Shimizu 1, 4, 7 , Yoshiyuki Hirano 1
Affiliation  

Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT. Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses. Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT . Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD. UMIN, UMIN00024087 . Registered 20 September 2016 - Retrospectively registered (including retrospective data).

中文翻译:

强迫症的暴露反应预测和基于反应预防的认知行为疗法。

认知行为疗法(CBT)包括暴露和反应预防(ERP),可有效改善强迫症(OCD)症状。然而,尚不清楚认知功能差和自闭症谱系(ASD)性状是否会影响OCD患者对基于ERP的CBT的治疗反应。这项研究旨在确定预测日本强迫症患者对基于ERP的CBT的治疗反应的因素。使用Wechsler成人智力量表III(WAIS-III),Yale-Brown强迫症量表,患者健康问卷9项量表和自闭症频谱商(AQ)对42位日本OCD门诊病人进行了评估。后处理。我们使用多元回归分析来估计对治疗反应改变的影响。在多重回归分析中,将治疗反应变化设为因变量。多元回归分析表明,在独立变量中,作为AQ子量表的交流和作为WAIS-III子测验的信号排序可预测对基于ERP的CBT的治疗反应。我们的研究结果表明,强迫症患者的工作记忆(字母序列)减少,沟通技巧(AQ量表)差可能损害对基于ERP的CBT的反应能力。UMIN,UMIN00024087。2016年9月20日注册-追溯注册(包括追溯数据)。我们的研究结果表明,强迫症患者的工作记忆(字母序列)减少,沟通技巧(AQ量表)差可能损害对基于ERP的CBT的反应能力。UMIN,UMIN00024087。2016年9月20日注册-追溯注册(包括追溯数据)。我们的研究结果表明,强迫症患者的工作记忆(字母序列)减少,沟通技巧(AQ量表)差可能损害对基于ERP的CBT的反应能力。UMIN,UMIN00024087。2016年9月20日注册-追溯注册(包括追溯数据)。
更新日期:2020-09-05
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