Photosensitizers (PSs), a critical drug administered for successful photodynamic therapy (PDT), have been well researched regarding their anticancer or bactericidal capability with high precision and low invasiveness. Although traditional PSs have been explored either in photodynamic anticancer or in antibiosis, they usually require synthesis with multiple steps, harsh synthetic conditions, and a complicated purification process for a single targeted product. Therefore, developing new multifunctional PSs with a simple synthesis and reactant flexibility which combine mitochondrial and bacterial imaging, efficient photodynamic anticancer and antibacterial effects is of the utmost urgency and of great importance for clinical applications. Herein, a large structural investigation of isoquinolinium-based PSs synthesized by a simple Rh-catalysed annulation reaction with high yields is presented. These lipophilic cationic PSs have a tunable photophysical property. LIQ-6 was found to perform not only as an ideal mitochondria targeting probe but also an effective cancer cell killing PS, and moreover, a tracker for bacterial imaging and ablation. LIQ-6 can be used to image a wide range of cancer cells and to monitor the photo-induced cell apoptosis, and simultaneously, it can also image and be a photodynamic germicide for both Gram-positive and Gram-negative bacteria. Furthermore, LIQ-6 shows great effectiveness in the wound healing process, showing its ability to be an ideal PS in vivo as well. This contribution is believed to offer a new platform for the construction of a theragnostic system for future practical applications in biology and biomedicine.

中文翻译：

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简单合成用于线粒体和细菌成像以及光动力抗癌和抗菌疗法的多功能光敏剂。

光敏剂（PSs）是成功进行光动力疗法（PDT）的重要药物，已经对其高精确度和低侵袭性的抗癌或杀菌能力进行了充分的研究。尽管已经在光动力抗癌或抗生中研究了传统的聚苯乙烯，但它们通常需要多个步骤进行合成，苛刻的合成条件以及单个目标产物的复杂纯化工艺。因此，具有线粒体和细菌成像，有效的光动力学抗癌和抗菌作用相结合的具有简单合成和反应灵活性的新型多功能PS迫在眉睫，对临床应用至关重要。在这里 提出了通过简单的Rh催化的高产率环化反应合成的基于异喹啉鎓的PS的大型结构研究。这些亲脂性阳离子PS具有可调的光物理性质。发现LIQ-6不仅可以用作理想的线粒体靶向探针，而且还可以有效杀死PS的癌细胞，而且还可以用作细菌成像和消融的追踪剂。LIQ-6可用于对各种癌细胞成像，并监测光诱导的细胞凋亡，同时，它还可对革兰氏阳性和革兰氏阴性细菌成像并成为光动力杀菌剂。此外，LIQ-6在伤口愈合过程中显示出巨大的功效，也显示出它也可以成为体内理想的PS的能力。相信该贡献将为构建用于未来生物学和生物医学中的实际应用的吻合术系统提供新平台。