Thermoplasmonic effect-based neural stimulation has been suggested as an alternative optical neural stimulation technology without genetic modification. Integration of near-infrared light with plasmonic gold nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test the validity of the thermoplasmonic neural stimulation across multiple biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in optical neuromodulation, versatile engineering approaches to apply the thermoplasmonic effect would be required. In this work, we developed a gold nanorod attached optical fiber technology for the localized neural stimulation based on a thermoplasmonic effect. A simple fabrication process was developed for efficient nanoparticle coating on commercial optical fibers. The thermoplasmonic optical fiber proved that it can locally modulate the neural activity in vitro. Lastly, we simulated the spatiotemporal temperature change by the thermoplasmonic optical fiber and analyzed its applicability to in vivo animal models.

中文翻译：

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用于局部神经刺激的热等离子体光纤。

已经提出了基于热等离子体效应的神经刺激，作为无需基因修饰的另一种光学神经刺激技术。近红外光与等离激元金纳米粒子的集成已被证明是体外神经元网络模型上的神经调节工具。为了进一步测试热等离子体神经刺激在多种生物学模型（体外，离体和体内）中的有效性）避免在光学神经调节中进行基因修饰，因此需要应用热等离子体效应的通用工程方法。在这项工作中，我们开发了一种金纳米棒附着光纤技术，用于基于热等离子体效应的局部神经刺激。开发了一种简单的制造工艺，可以在商用光纤上进行有效的纳米颗粒涂层。热等离子体光纤证明它可以局部调节体外神经活动。最后，我们模拟了热等离子体光纤的时空温度变化，并分析了其在体内动物模型中的适用性。