当前位置: X-MOL 学术Bioinformatics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Characterizing therapeutic signatures of transcription factors in cancer by incorporating profiles in compound treated cells.
Bioinformatics ( IF 5.8 ) Pub Date : 2020-09-04 , DOI: 10.1093/bioinformatics/btaa765
Jinmyung Jung 1
Affiliation  

Cancers are promoted by abnormal alterations in biological processes, such as cell cycle and apoptosis. An immediate reason for those aberrant processes is the deregulation of their involved transcription factors (TFs). Thus, the deregulated TFs in cancer have been experimented as successful therapeutic targets, such as RARA and RUNX1. This therapeutic strategy can be accelerated by characterizing new potential TF targets.

中文翻译:

通过在化合物处理的细胞中整合谱来表征癌症中转录因子的治疗特征。

生物学过程的异常改变(例如细胞周期和凋亡)促进了癌症的发展。这些异常过程的直接原因是其相关转录因子(TF)的失控。因此,已经将癌症中失活的TFs作为RARA和RUNX1等成功的治疗靶标进行了实验。可以通过表征新的潜在TF靶点来加速这种治疗策略。
更新日期:2020-09-05
down
wechat
bug