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Directly self-assembling method to easily prepare rough silk fibroin film
Soft Materials ( IF 1.2 ) Pub Date : 2020-09-04 , DOI: 10.1080/1539445x.2020.1815772
Guotao Cheng 1 , Xin Wang 2 , Chunxiao Song 1 , Xiaoning Zhang 1
Affiliation  

ABSTRACT

The surface roughness of silk fibroin biomaterials affects the adhesion and growth of cells on their surface. Silk fibroin molecules exhibit the natural ability to self-assemble. By utilizing this feature, a silk fibroin film with rough surfaces can be easily prepared. Scanning electron microscopy and atomic force microscopy results showed micro-/nanoscale protrusions with a uniform distribution over the film surface. The film structure characterization and dynamic light scattering results confirmed that this is because the silk fibroin molecules self-assemble in solution to form relatively large aggregates. These aggregates penetrate the surface of the film during drying, thereby forming these tiny protrusions on the film surface. Furthermore, the results of the cell adhesion test prove that this rough surface is more conducive to cell adhesion and growth thereon.



中文翻译:

直接自组装法轻松制备粗丝素膜

摘要

丝素蛋白生物材料的表面粗糙度影响细胞在其表面的粘附和生长。丝素蛋白分子表现出自组装的天然能力。利用这一特性,可以很容易地制备表面粗糙的丝素蛋白薄膜。扫描电子显微镜和原子力显微镜结果显示在薄膜表面具有均匀分布的微米/纳米级突起。薄膜结构表征和动态光散射结果证实,这是因为丝素蛋白分子在溶液中自组装形成较大的聚集体。这些聚集体在干燥过程中渗入薄膜表面,从而在薄膜表面形成这些微小的突起。此外,

更新日期:2020-09-04
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