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Coexistence of peripheral potentiation and corticospinal inhibition following a conditioning contraction in human first dorsal interosseous muscle.
Journal of Applied Physiology ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1152/japplphysiol.00238.2020
Cameron Blair Smith 1 , Matti Douglas Allen 1, 2, 3 , Charles L Rice 1, 4
Affiliation  

In skeletal muscle, post-activation potentiation (PAP) is observed following a conditioning contraction (CC) as a large (2- to 3-fold) increase in evoked twitch force and rate of force development (RFD). However, this enhancement has not been observed to occur during potentiated voluntary contractions. The purpose of this study was to determine if the lack of voluntary potentiation may be related to the development of central (corticospinal) inhibition. Participants (N=10, all males) completed voluntary and evoked index finger abduction contractions and transcranial magnetic stimulated (TMS) motor evoked potentials (MEP) of the motor cortex were recorded from the first dorsal interosseous (FDI). Central inhibition was assessed by measuring the silent period following the MEP. The FDI was potentiated via 10s conditioning contractions at 60% of maximal index finger abduction strength, using both voluntary and evoked tetanic contractions. Immediately following CC and transcutaneous electrical twitches. Following both voluntary and tetanic CC, force and RFD of the twitch were similarly increased (~200% and ~160% respectively). The silent period was elongated by ~10% following both forms of CC. These results indicate that corticospinal inhibition does occur following CC, but that it is unrelated to the voluntary activation during the CC. These results also show that following CC, the positive contractile effects at the muscle are concurrently accompanied by inhibitory effects at the corticospinal level.

中文翻译:

人类第一背骨间肌调节收缩后外周增强和皮质脊髓抑制的共存。

在骨骼肌中,在调节收缩 (CC) 后观察到激活后增强 (PAP) 作为诱发抽搐力和力发展速率 (RFD) 的大 (2 至 3 倍) 增加。然而,在增强的自主收缩期间尚未观察到这种增强。本研究的目的是确定自愿增强的缺乏是否与中枢(皮质脊髓)抑制的发展有关。参与者(N = 10,所有男性)完成自愿和诱发食指外展收缩和经颅磁刺激(TMS)运动皮层运动诱发电位(MEP)从第一背侧骨间(FDI)记录。通过测量 MEP 后的静默期来评估中枢抑制。外国直接投资通过 10 秒调节收缩以最大食指外展强度的 60% 增强,使用自愿和诱发的强直收缩。紧接着 CC 和经皮电抽搐。在自愿和强直性 CC 之后,抽搐的力和 RFD 类似地增加(分别为~200% 和~160%)。在两种形式的 CC 之后,沉默期延长了约 10%。这些结果表明皮质脊髓抑制确实发生在 CC 后,但它与 CC 期间的自愿激活无关。这些结果还表明,在 CC 之后,肌肉的积极收缩作用同时伴随着皮质脊髓水平的抑制作用。紧接着 CC 和经皮电抽搐。在自愿和强直性 CC 之后,抽搐的力和 RFD 类似地增加(分别为~200% 和~160%)。在两种形式的 CC 之后,沉默期延长了约 10%。这些结果表明皮质脊髓抑制确实发生在 CC 后,但它与 CC 期间的自愿激活无关。这些结果还表明,在 CC 之后,肌肉的积极收缩作用同时伴随着皮质脊髓水平的抑制作用。紧接着 CC 和经皮电抽搐。在自愿和强直性 CC 之后,抽搐的力和 RFD 类似地增加(分别为~200% 和~160%)。在两种形式的 CC 之后,沉默期延长了约 10%。这些结果表明皮质脊髓抑制确实发生在 CC 后,但它与 CC 期间的自愿激活无关。这些结果还表明,在 CC 之后,肌肉的积极收缩作用同时伴随着皮质脊髓水平的抑制作用。这些结果表明皮质脊髓抑制确实发生在 CC 后,但它与 CC 期间的自愿激活无关。这些结果还表明,在 CC 之后,肌肉的积极收缩作用同时伴随着皮质脊髓水平的抑制作用。这些结果表明皮质脊髓抑制确实发生在 CC 后,但它与 CC 期间的自愿激活无关。这些结果还表明,在 CC 之后,肌肉的积极收缩作用同时伴随着皮质脊髓水平的抑制作用。
更新日期:2020-09-05
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