Among the follicular fluid (FF) components promoting the development of the oocyte are included glycoproteins, several fatty acids, and steroid hormones synthesized by the dominant follicle. For this, the analysis of the metabolites present in FF can determine the quality of the oocyte. FF composition is in part determined by local follicular metabolic processes and in part a plasma transudate. Since the causes of impaired fertility may be due to a metabolic imbalance, metabolomics is useful to identify low molecular weight metabolites. Oxidative stress is involved in human infertility and the use of metabolomics can be crucial to identify which other metabolites besides reactive oxygen species are involved in oxidative stress correlated to infertility. To obtain new information on the study of signaling molecules in FF, the knowledge of the lipid content will be important to improve information on the understanding of follicular development. The objective of this study is to identify (a) a metabolic profile and a lipid profile of FF in women undergoing in vitro fertilization and (b) to correlate the previous information obtained regarding adiponectin and oxidative stress with the metabolic and lipid profile obtained in the present study. As result, we found an increase in oxidative stress due to both an increase of androgens and an accumulation of lipids in the follicular environment and we suggest that this might be one of the causes of reduced fertility.

中文翻译：

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体外受精妇女卵泡液中代谢与脂质分布之间的关系。

促进卵母细胞发育的卵泡液（FF）成分包括糖蛋白，几种脂肪酸和由优势卵泡合成的类固醇激素。为此，对FF中存在的代谢产物的分析可以确定卵母细胞的质量。FF组成部分取决于局部的卵泡代谢过程，部分取决于血浆渗出液。由于生育力受损的原因可能是由于代谢失衡，因此代谢组学可用于鉴定低分子量代谢物。氧化应激与人类不育症有关，代谢组学的使用对于确定除活性氧以外的其他代谢物是否与不育症相关的氧化应激至关重要。为了获得有关FF中信号分子研究的新信息，脂质含量的知识对于改善对卵泡发育的了解的信息至关重要。这项研究的目的是确定（a）进行体外受精的妇女的FF的代谢特征和脂质特征，以及（b）将先前获得的有关脂联素和氧化应激的信息与通过脂联素获得的代谢和脂质特征相关联。目前的学习。结果，我们发现由于雄激素的增加和卵泡环境中脂质的积累，氧化应激的增加，我们建议这可能是生育力降低的原因之一。这项研究的目的是确定（a）进行体外受精的妇女的FF的代谢特征和脂质特征，以及（b）将先前获得的有关脂联素和氧化应激的信息与通过脂联素获得的代谢和脂质特征相关联。目前的学习。结果，我们发现由于雄激素的增加和卵泡环境中脂质的积累，氧化应激的增加，我们建议这可能是生育力降低的原因之一。这项研究的目的是确定（a）进行体外受精的妇女的FF的代谢特征和脂质特征，以及（b）将先前获得的有关脂联素和氧化应激的信息与通过脂联素获得的代谢和脂质特征相关联。目前的学习。结果，我们发现由于雄激素的增加和卵泡环境中脂质的积累，氧化应激的增加，我们建议这可能是生育力降低的原因之一。