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Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification.
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-09-04 , DOI: 10.1111/jcmm.15793
Natália Tőkési 1 , Eszter Kozák 1 , Krisztina Fülöp 1 , Dóra Dedinszki 1 , Nikolett Hegedűs 2 , Bálint Király 2, 3 , Krisztián Szigeti 2 , Kitti Ajtay 4 , Zoltán Jakus 4 , Jeremy Zaworski 5, 6 , Emmanuel Letavernier 5, 6 , Viola Pomozi 1 , András Váradi 1
Affiliation  

Trauma‐induced calcification is the pathological consequence of complex injuries which often affect the central nervous system and other parts of the body simultaneously. We demonstrated by an animal model recapitulating the calcification of the above condition that adrenaline transmits the stress signal of brain injury to the calcifying tissues. We have also found that although the level of plasma pyrophosphate, the endogenous inhibitor of calcification, was normal in calcifying animals, it could not counteract the acute calcification. However, externally added pyrophosphate inhibited calcification even when it was administered after the complex injuries. Our finding suggests a potentially powerful clinical intervention of calcification triggered by polytrauma injuries which has no effective treatment.

中文翻译:

焦磷酸盐疗法可在神经源性异位骨化的小鼠模型中防止创伤引起的钙化。

创伤引起的钙化是复杂损伤的病理结果,这些损伤通常同时影响中枢神经系统和身体其他部位。我们通过概括上述条件的钙化的动物模型证明,肾上腺素将脑损伤的应激信号传递至钙化组织。我们还发现,尽管钙化动物血浆中的内源性钙化抑制剂焦磷酸盐的水平是正常的,但它不能抵消急性钙化。然而,即使在复杂的损伤后施用,外部添加的焦磷酸盐也抑制钙化。我们的发现表明,潜在的有效的多发伤致钙化的临床干预措施尚无有效的治疗方法。
更新日期:2020-10-22
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