Obesity is a critical risk factor causing the development of metabolic diseases and cancers. Its increasing prevalence worldwide has aroused great concerns of the researchers on adipose development and metabolic function. During adipose expansion, adipogenesis is a way to store lipids as well as to avoid lipotoxicity in other tissues, and may be an approach to offset the negative metabolic effects of obesity. In this Review, the transcriptional regulation of adipogenesis is outlined to characterize numerous biological processes in research on the determination of adipocyte fate and regulation of adipogenic differentiation. Notably, one of the post‐transcriptional modifications of mRNA, namely, N⁶‐methyladenosine (m⁶A), has been recently found to play a role in adipogenesis. Here, the roles of m⁶A‐related enzymes and proteins in adipogenesis, with a particular focus on how these m⁶A‐related proteins function at different stages of adipogenesis, are mainly discussed. The Review also highlights the coordination role of the transcriptional and post‐transcriptional (RNA m⁶A methylation) regulation in adipogenesis and related biological processes. In this context, a better understanding of adipogenesis at both the transcriptional and post‐transcriptional levels may facilitate the development of novel strategies to improve metabolic health in obesity.

中文翻译：

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从转录和 RNA N6-甲基腺苷介导的转录后调控角度对脂肪生成的新见解

肥胖是导致代谢疾病和癌症发生的关键危险因素。其在全球范围内的日益流行引起了研究人员对脂肪发育和代谢功能的高度关注。在脂肪扩张过程中，脂肪生成是储存脂质以及避免其他组织中的脂毒性的一种方式，并且可能是抵消肥胖的负面代谢影响的一种方法。在这篇综述中，概述了脂肪生成的转录调控，以表征脂肪细胞命运的确定和脂肪生成分化的调控研究中的许多生物过程。值得注意的是，最近发现 mRNA 的转录后修饰之一，即 N ⁶ -甲基腺苷 (m ⁶ A) 在脂肪生成中发挥作用。^{本文主要讨论 m 6} A 相关酶和蛋白质在脂肪生成中的作用，特别关注这些 m ⁶ A 相关蛋白在脂肪生成的不同阶段如何发挥作用。该综述还强调了转录和转录后（RNA m ^6A甲基化）调节在脂肪生成和相关生物过程中的协调作用。在这种情况下，更好地了解转录和转录后水平的脂肪生成可能有助于开发改善肥胖代谢健康的新策略。