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Past, present and future EEG in the clinical workup of dementias
Psychiatry Research: Neuroimaging ( IF 2.3 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.pscychresns.2020.111182
Thomas Koenig 1 , Una Smailovic 2 , Vesna Jelic 3
Affiliation  

Electroencephalography (EEG), as non-invasive, global measure of neuronal activity, is a prime candidate functional marker of synapse dysfunction and loss in dementias. Nevertheless, EEG currently has no established role in the clinical workup of individual patients. This opinion paper presents our critical view on why EEG has so far failed to keep its promise, and where we believe EEG will be clinically useful for patients threatened with cognitive decline in the future. Individual EEGs are an integral outcome of many causally intermixing upstream factors contributing to dementia. Therefore, EEG cannot become a clinically useful "simple" stand-alone biomarker of some pathognomic accumulations of specific brain proteins, but rather offer unique opportunities for more comprehensive and richly faceted insights into the functional status of brain systems. EEG may thus remain an essential window into the brain when it comes to the at-risk and presymptomatic phases of dementias, where it can be uniquely informative about concepts such as burdens of plasticity and repair, cognitive reserve, and sleep. Jointly with rapid gains in usability, portability, machine learning, closed loop systems, and understanding of the role of EEG-based sleep stages for memory and brain repair, EEG may come to keep its initial promise after all.

中文翻译:

过去、现在和未来脑电图在痴呆临床检查中的作用

脑电图 (EEG) 作为神经元活动的非侵入性全局测量,是突触功能障碍和痴呆症丧失的主要候选功能标志物。尽管如此,脑电图目前在个体患者的临床检查中还没有确定的作用。这份意见书提出了我们的批判性观点,即为什么 EEG 迄今未能兑现其承诺,以及我们认为 EEG 将在临床上对未来面临认知衰退威胁的患者有用的地方。单个脑电图是导致痴呆症的许多因果混合上游因素的综合结果。因此,脑电图不能成为临床上有用的“简单”的特定脑蛋白的某些病理学积累的独立生物标志物,而是提供独特的机会,以更全面、更丰富地洞察大脑系统的功能状态。因此,当涉及到痴呆症的风险和症状前阶段时,脑电图可能仍然是进入大脑的重要窗口,在那里它可以提供关于可塑性和修复负担、认知储备和睡眠等概念的独特信息。随着可用性、便携性、机器学习、闭环系统以及对基于 EEG 的睡眠阶段对记忆和大脑修复作用的理解的快速提高,EEG 可能终将实现其最初的承诺。认知储备和睡眠。随着可用性、便携性、机器学习、闭环系统以及对基于 EEG 的睡眠阶段对记忆和大脑修复作用的理解的快速提高,EEG 可能终将实现其最初的承诺。认知储备和睡眠。随着可用性、便携性、机器学习、闭环系统以及对基于 EEG 的睡眠阶段对记忆和大脑修复作用的理解的快速提高,EEG 可能终将实现其最初的承诺。
更新日期:2020-12-01
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