当前位置:
X-MOL 学术
›
J. Struct. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A NEW THREE-DIMENSIONAL Co(II)-BASED COORDINATION POLYMER: TREATMENT ACTIVITY IN OBESITY MODEL IN VITRO AND IN VIVO BY INCREASING THE LEVEL OF LEPTIN
Journal of Structural Chemistry ( IF 0.8 ) Pub Date : 2020-07-01 , DOI: 10.1134/s0022476620070185 S Z Cui , Q D Ye , Y Chen , D Q Mao , Q Y Dai , N Li , G Xiao
Journal of Structural Chemistry ( IF 0.8 ) Pub Date : 2020-07-01 , DOI: 10.1134/s0022476620070185 S Z Cui , Q D Ye , Y Chen , D Q Mao , Q Y Dai , N Li , G Xiao
Abstract A new 3-dimensional (3D) Co(II)-based coordination polymer, namely, {[Co(L 1 )](H 2 O)} n (H 2 O) ( 1 ) (H 2 L 1 = 3,3′-(pyridine-3,5-diyl) dibenzoic acid), is synthesized under the solvothermal reaction conditions. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano- 1 hereafter). Furthermore, the biological function of the compound is evaluated on the obesity model and the related mechanism is explored. RT-PCR is performed for the evaluation of the leptin gene expression in adipose cells after treating with the compound. ELISA is conducted to determine the leptin content in adipose tissues in vivo after treatment with the compound.
中文翻译:
一种新的基于三维 Co(II) 的配位聚合物:通过增加瘦素水平在体外和体内肥胖模型中的治疗活性
摘要 一种新的基于 3D (3D) Co(II) 的配位聚合物,即 {[Co(L 1 )](H 2 O)} n (H 2 O) ( 1 ) (H 2 L 1 = 3 ,3'-(pyridine-3,5-diyl) dibenzoic acid),在溶剂热反应条件下合成。此外,实施了生手研磨技术以减小复合物1的粒径以产生纳米级1(以下表示为nano-1)。此外,在肥胖模型上评估了该化合物的生物学功能,并探讨了相关机制。进行 RT-PCR 以评估用化合物处理后脂肪细胞中瘦素基因的表达。进行ELISA以确定用该化合物处理后体内脂肪组织中的瘦素含量。
更新日期:2020-07-01
中文翻译:
一种新的基于三维 Co(II) 的配位聚合物:通过增加瘦素水平在体外和体内肥胖模型中的治疗活性
摘要 一种新的基于 3D (3D) Co(II) 的配位聚合物,即 {[Co(L 1 )](H 2 O)} n (H 2 O) ( 1 ) (H 2 L 1 = 3 ,3'-(pyridine-3,5-diyl) dibenzoic acid),在溶剂热反应条件下合成。此外,实施了生手研磨技术以减小复合物1的粒径以产生纳米级1(以下表示为nano-1)。此外,在肥胖模型上评估了该化合物的生物学功能,并探讨了相关机制。进行 RT-PCR 以评估用化合物处理后脂肪细胞中瘦素基因的表达。进行ELISA以确定用该化合物处理后体内脂肪组织中的瘦素含量。