Purpose

The use of ⁶⁸Ga-labelled carbon nanoparticles has been proposed for lung ventilation PET/CT imaging. However, no study has assessed the physical properties of ⁶⁸Ga-labelled carbon nanoparticles. The aim of this study therefore was to evaluate the shape and size of ⁶⁸Ga-labelled carbon nanoparticles, and to determine the composition of the aerosol, as opposed to ^99mTc-labelled carbon nanoparticles aerosol.

Procedures

^99mTc- and ⁶⁸Ga-labelled carbon nanoparticles, stable gallium carbon nanoparticles, 0.9 % NaCl and 0.1 N HCl-based carbon nanoparticles were produced using an unmodified Technegas® generator, following the usual technique used for clinical Technegas® production. The shape and size of particles were studied by transmission electron microscopy (TEM) after decay of the radioactive samples. The composition of the ⁶⁸Zn- and ⁹⁹Tc-labelled carbon nanoparticles aerosols was assessed using scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) analysis after decay of the ⁶⁸Ga- and ^99mTc-labelled carbon nanoparticles, respectively.

Results

On TEM, all samples showed similar shape with hexagonally structured primary particles, agglomerated in clusters. The mean diameters of primary stable gallium carbon nanoparticles, ⁹⁹Tc- and ⁶⁸Zn-labelled carbon nanoparticles were 22.4 ± 10 nm, 20.9 ± 7.2 nm and 19.8 ± 11.7 nm, respectively.

Conclusion

Using Technegas® generator in the usual clinical way, ^99mTc- and ⁶⁸Ga-labelled carbon nanoparticles demonstrated similar shape and diameters in the same size range size. These results support the use of ⁶⁸Ga-labelled carbon nanoparticles for the assessment of regional lung ventilation function with PET imaging.

中文翻译：

---

用于通气 PET/CT 成像的 68Ga 标记碳纳米颗粒：物理特性研究和与锝气体的比较。

目的

已提议将⁶⁸ Ga 标记的碳纳米粒子用于肺通气 PET/CT 成像。然而，没有研究评估⁶⁸ Ga 标记的碳纳米粒子的物理特性。因此，本研究的目的是评估⁶⁸ Ga 标记的碳纳米粒子的形状和大小，并确定气溶胶的组成，而不是^99m Tc 标记的碳纳米粒子气溶胶。

程序

^99m Tc 和⁶⁸ Ga 标记的碳纳米颗粒、稳定的镓碳纳米颗粒、0.9 % NaCl 和 0.1 N HCl 基碳纳米颗粒是使用未经改进的锝气体发生器生产的，遵循临床锝生产常用的技术。在放射性样品衰变后，通过透射电子显微镜 (TEM) 研究颗粒的形状和大小。在⁶⁸ Ga 和^99m Tc 标记的碳纳米粒子衰变后，使用扫描电子显微镜 (SEM) 结合能量色散 X 射线 (EDX) 分析评估了⁶⁸ Zn 和⁹⁹ Tc 标记的碳纳米粒子气溶胶的组成，分别。

结果

在 TEM 上，所有样品都显示出相似的形状，具有六边形结构的初级粒子，聚集成簇。初级稳定的镓碳纳米粒子、⁹⁹ Tc 和⁶⁸ Zn 标记的碳纳米粒子的平均直径分别为 22.4 ± 10 nm、20.9 ± 7.2 nm 和 19.8 ± 11.7 nm。

结论

以通常的临床方式使用^锝气体发生器，^99m Tc 和⁶⁸ Ga 标记的碳纳米粒子在相同的尺寸范围内表现出相似的形状和直径。这些结果支持使用⁶⁸ Ga 标记的碳纳米粒子通过 PET 成像评估区域肺通气功能。