Every disease is an outcome of one or more stress signals which get convened at the interface of the mitochondria. Mitochondria and metabolism are inextricably anchored to each other and a disruption in either can result in the generation of stressors, which can lead to detrimental health consequences. Stowing everything in one frame reflects that the proteins involved in the sensing of stressors are fundamental for the initiation of various pathologies and their detailed study is necessary for proper understanding of disease mechanisms. Sestrins, a class of evolutionarily conserved, stress inducible genes are activated by a wide range of stressors such as oxidative, genotoxic, and metabolic and play a role in cellular homeostasis. In addition, recent reports have highlighted their importance in governing the mitochondrial dynamics and metabolism. However, their spectrum of involvement in various pathologies has not been dissected out very well. This review will focus and discuss the role of Sestrins mainly Sestrin2 and associated nexus in the context of mitochondria, metabolism, and health.

每种疾病都是一种或多种压力信号的结果，这些信号在线粒体的界面处聚集。线粒体和新陈代谢密不可分，任何一种破坏都可能导致压力源的产生，从而可能对健康造成不利影响。将所有东西存放在一个框架中反映了参与应激源感测的蛋白质是引发各种病理的基础，对它们的详细研究对于正确理解疾病机理是必需的。Sestrins是一类在进化上保守的，压力诱导型基因，可被多种压力源（例如氧化，遗传毒性和代谢）激活，并在细胞体内平衡中发挥作用。另外，最近的报道强调了它们在控制线粒体动力学和代谢中的重要性。然而，他们参与各种病理的范围还没有很好地剖析。这篇综述将集中讨论线粒体，新陈代谢和健康方面，主要是雌激素Sestrin2和相关的联系的作用。