当前位置: X-MOL 学术Mol. Cell. Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Chromosomal terminal methylation status is associated with gut microbiotic alterations.
Molecular and Cellular Biochemistry ( IF 4.3 ) Pub Date : 2020-09-04 , DOI: 10.1007/s11010-020-03892-7
Toyoki Maeda 1 , Takahiko Horiuchi 1 , Naoki Makino 1
Affiliation  

We explored the association of fecal bacterial species and somatic telomere changes in patients with chronic disease. The results showed that the length of the combined range of telomere and the methylated subtelomere was correlated with the increase of bacteria species and the numerical superiority of certain strains in feces, the increase of streptococci in men and women, and the increase of E. coli specifically in women. These results suggest that the aging status reflected by telomere length and/or demethylation of neighboring regions correlate with intestinal conditions which influences the proportion of the intestinal microbial population. Shortened telomere length and subtelomeric demethylation status are thought to represent the degree of aging and the accelerating stage of aging velocity, respectively. Hence, the observed biased microbial status is considered to be associated with advanced stage or acceleration phase of biological aging.



中文翻译:

染色体末端甲基化状态与肠道微生物改变相关。

我们探讨了慢性病患者粪便细菌种类与体细胞端粒变化的关系。结果表明,端粒和甲基化亚端粒组合范围的长度与粪便中细菌种类的增加和某些菌株的数量优势、男性和女性中链球菌的增加以及大肠杆菌的增加相关特别是在女性中。这些结果表明,端粒长度和/或邻近区域的去甲基化反映的衰老状态与影响肠道微生物种群比例的肠道状况相关。端粒长度缩短和亚端粒去甲基化状态被认为分别代表衰老程度和衰老速度的加速阶段。因此,观察到的有偏差的微生物状态被认为与生物衰老的晚期或加速阶段相关。

更新日期:2020-09-05
down
wechat
bug