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Motility of Vibrio spp.: regulation and controlling strategies.
Applied Microbiology and Biotechnology ( IF 5 ) Pub Date : 2020-08-20 , DOI: 10.1007/s00253-020-10794-7
Fazlurrahman Khan 1 , Nazia Tabassum 2 , Raksha Anand 3 , Young-Mog Kim 1, 4
Affiliation  

Abstract

Flagellar motility in bacteria is a highly regulated and complex cellular process that requires high energy investment for movement and host colonization. Motility plays an important role in the lifestyle of Vibrio spp. in the aquatic environment and during host colonization. Flagellar motility in vibrios is associated with several cellular processes, such as movement, colonization, adhesion, biofilm formation, and virulence. The transcription of all flagella-related genes occurs hierarchically and is regulated positively or negatively by several transcription factors and regulatory proteins. The flagellar regulatory hierarchy is well studied in Vibrio cholerae and Vibrio parahaemolyticus. Here, we compared the regulatory cascade and molecules involved in the flagellar motility of V. cholerae and V. parahaemolyticus in detail. The evolutionary relatedness of the master regulator of the polar and lateral flagella in different Vibrio species is also discussed. Although they can form symbiotic associations of some Vibrio species with humans and aquatic organisms can be harmed by several species of Vibrio as a result of surface contact, characterized by flagellar movement. Thus, targeting flagellar motility in pathogenic Vibrio species is considered a promising approach to control Vibrio infections. This approach, along with the strategies for controlling flagellar motility in different species of Vibrio using naturally derived and chemically synthesized compounds, is discussed in this review.

Key points

• Vibrio species are ubiquitous and distributed across the aquatic environments.

• The flagellar motility is responsible for the chemotactic movement and initial colonization to the host.

• The transition from the motile into the biofilm stage is one of the crucial events in the infection.

• Several signaling pathways are involved in the motility and formation of biofilm.

• Attenuation of motility by naturally derived or chemically synthesized compounds could be a potential treatment for preventing Vibrio biofilm-associated infections.



中文翻译:

弧菌的运动性:调节和控制策略。

摘要

细菌中的鞭毛运动是一个高度调节和复杂的细胞过程,需要大量的能量投入用于运动和宿主定殖。运动性在弧菌的生活方式中起着重要作用。在水生环境和寄主定居期间。弧菌的鞭毛运动与几种细胞过程有关,例如运动,定植,粘附,生物膜形成和毒力。所有鞭毛相关基因的转录是分层发生的,并受到几种转录因子和调节蛋白的正向或负向调节。鞭毛调节等级在霍乱弧菌副溶血弧菌中得到了很好的研究。在这里,我们比较了霍乱弧菌副溶血弧菌鞭毛运动的调控级联和分子。还讨论了不同弧菌物种中极鞭毛和侧鞭毛主调节器的进化相关性。尽管它们可以形成某些弧菌物种与人类的共生联系,但由于表面接触(特征是鞭毛运动),水生生物可能会受到几种弧菌的伤害。因此,在病原性弧菌中靶向鞭毛运动被认为是控制弧菌的 一种有前途的方法 感染。本文讨论了这种方法,以及使用天然衍生和化学合成的化合物控制弧菌不同物种鞭毛运动的策略。

关键点

•弧菌种无处不在,分布在整个水生环境中。

•鞭毛运动负责趋化运动和向宿主的最初定植。

•从运动到生物膜阶段的过渡是感染的关键事件之一。

•几种信号传导途径参与了生物膜的运动和形成。

•天然来源或化学合成的化合物可降低运动能力,这可能是预防与弧菌生物膜相关感染的潜在疗法。

更新日期:2020-09-05
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