Background/Aim: The aim of the study was to evaluate the effect of rutin, which is a vitamin P1 flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats. Materials and Methods: Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically. Results: We found that the levels of malondialdehyde, nuclear factor-kappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema. Conclusion: Rutin might be effective in the treatment of TBI and TBI-related brain edema.

中文翻译：

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芦丁对大鼠实验性外伤性脑损伤和水肿的影响

背景/目的：该研究的目的是评估芦丁（一种具有抗炎和抗水肿作用的维生素 P1 黄酮类化合物）对大鼠创伤性脑损伤 (TBI) 和水肿的影响。材料与方法：将大鼠分为无脑外伤（SG）假手术组、无脑外伤（BT）组和芦丁治疗脑外伤（RBT）组3组。RBT 组每天一次给予 50 mg/kg 芦丁，持续三天。第四天，处死大鼠。对提取的脑组织进行生化和组织病理学检查。结果：我们发现丙二醛、核因子-κB和肿瘤坏死因子-α水平降低，总谷胱甘肽水平显着升高。此外，芦丁给药减少了由于脑组织创伤引起的锥体神经元变性和多形核白细胞积聚，同时消除了水肿。结论：芦丁可有效治疗TBI及TBI相关脑水肿。