Background/Aim: Translation plays an important role in the carcinogenesis of various human tumors. Paip1 and eIF4A1 are translation-associated proteins that mediate the function of eukaryotic initiation factor 4F complex. This study aimed to analyse the relationship between the expression status of Paip1 and eIF4A1 and clinicopathologic features in hepatocellular carcinoma (HCC). Materials and Methods: Immunohistochemical analysis was used to evaluate the expression status of Paip1 and eIF4A1. Two pathologists independently interpreted the immunostained slides. The prognostic value of Paip1 and eIF4A1 was evaluated by the Kaplan–Meier plotter. Results: Among 173 HCC patients, 28 (16.1%) and 46 (26.6%) belonged in the Paip1 and eIF4A1 high-expression groups. High expression of Paip1 and eIF4A1 was associated with advanced TNM stage and more frequent vascular tumor invasion. Univariate analysis indicated that high Paip1 expression was associated with worse five-year overall survival (OS). Public dataset analysis by Kaplan–Meier plotter revealed that high mRNA expression of Paip1, and not of eIF4A1, was significantly associated with worse five-year OS and disease-free survival. Conclusion: Paip1 expression has a potential prognostic value in human HCC.

中文翻译：

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Paip1 高表达作为肝细胞癌的潜在预后标志物

背景/目的：翻译在各种人类肿瘤的致癌过程中发挥着重要作用。Paip1 和 eIF4A1 是翻译相关蛋白，可介导真核起始因子 4F 复合物的功能。本研究旨在分析 Paip1 和 eIF4A1 的表达状态与肝细胞癌 (HCC) 临床病理特征之间的关系。材料与方法：免疫组织化学分析用于评估 Paip1 和 eIF4A1 的表达状态。两名病理学家独立解读免疫染色载玻片。通过 Kaplan-Meier 绘图仪评估 Paip1 和 eIF4A1 的预后价值。结果：173例HCC患者中，28例（16.1%）和46例（26.6%）属于Paip1和eIF4A1高表达组。Paip1 和 eIF4A1 的高表达与晚期 TNM 分期和更频繁的血管肿瘤侵袭有关。单变量分析表明，高 Paip1 表达与较差的五年总生存期 (OS) 相关。Kaplan-Meier 绘图仪的公共数据集分析显示，Paip1 的高 mRNA 表达，而不是 eIF4A1 的高表达，与较差的 5 年 OS 和无病生存率显着相关。结论：Paip1 表达在人类 HCC 中具有潜在的预后价值。