Background/Aim: To evaluate the association between TRIB1(rs6987702) and IL-9(rs1859430, rs2069870) genotypes with the development and manifestation of pituitary adenoma (PA). Materials and Methods: The study group included 141 patients with PA and the control group consisted of 287 healthy people. The genotyping of rs6987702, rs1859430 and rs2069870 was carried out using a real-time polymerase chain reaction. Results: Statistically significant results were obtained regarding the rs1859430, but there were no significant results regarding rs6987702. We found that the rs1859430 A/A genotype increased the odds of having recurrent PA six times (p=0.006) under the co-dominant model and four times (p=0.021) under the recessive model. Furthermore, the analysis showed that the G/A genotype increased the odds of having recurrent PA 2.3 times (p=0.003) under the co-dominant model, while G/A and A/A genotypes increased the odds 2.7 times (p=0.011) under the over-dominant model. Conclusion: Certain genotypes of rs1859430 can be associated with PA recurrence.

中文翻译：

---

TRIB1 和 IL-9 基因多态性会影响垂体腺瘤的发展和表现吗？

背景/目的：评估TRIB1（rs6987702）和IL-9（rs1859430，rs2069870）基因型与垂体腺瘤（PA）的发展和表现之间的关联。材料与方法：研究组包括141名PA患者，对照组包括287名健康人。使用实时聚合酶链式反应对 rs6987702、rs1859430 和 rs2069870 进行基因分型。结果：关于 rs1859430 获得了统计上显着的结果，但没有关于 rs6987702 的显着结果。我们发现 rs1859430 A/A 基因型在共显性模型下将复发性 PA 的几率增加了六倍（p=0.006），在隐性模型下增加了四倍（p=0.021）。此外，分析表明，G/A 基因型使 PA 复发的几率增加了 2.3 倍（p=0. 003）在共显性模型下，而 G/A 和 A/A 基因型在超​​显性模型下增加了 2.7 倍（p=0.011）的几率。结论：rs1859430的某些基因型可能与PA复发有关。