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Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors
In Vivo ( IF 2.3 ) Pub Date : 2020-01-01 , DOI: 10.21873/invivo.12087
Vladislav Treska 1 , Martin Skala 2 , Kristyna Prochazkova 2 , Aneta Svejdova 2 , Tereza Petrakova 2 , Jakub Sebek 2 , Ivan Riha 2 , Jachym Rosendorf 2 , Robert Polak 2 , Tomas Skalicky 2 , Vaclav Liska 2
Affiliation  

Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3- and 5-year OS and RFS were independent of primary tumour location (p<0.59). CLM diameter was negatively associated with OS for the whole cohort (p<0.002), and RCRC (p<0.03) and LCRC (p<0.04) groups, as well as for RFS of those with LCRC (p<0.04). CLM number was negatively associated with RFS for the whole cohort (p<0.0001), RCRC (p<0.02), LCRC (p<0.0001) and RC (p<0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p<0.03), and to worse RFS for the whole cohort (p<0.0003) and for those with LCRC (p<0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p<0.05), LCRC (p<0.05) and RC (p<0.02). Conclusion: Primary tumour location together with clinical risk factors are important for long-term results of surgery CLMs.

中文翻译:

从原发性肿瘤位置和临床危险因素来看,结直肠肝转移手术的长期结果

背景/目的:本研究的目的是评估原发肿瘤位置和临床危险因素对结直肠肝转移 (CLM) 手术长期结果的影响。患者和方法:评估了 636 名患者的总生存期 (OS) 和无复发生存期 (RFS)。患者按肿瘤位置(右侧/左侧结直肠癌:RCRC/LCRC;直肠癌)进行划分,并评估年龄、性别、CLM 的数量和大小、肝脏手术类型和初次手术的间隔。结果:1 年、3 年和 5 年 OS 和 RFS 与原发肿瘤位置无关(p<0.59)。CLM 直径与整个队列 (p<0.002)、RCRC (p<0.03) 和 LCRC (p<0.04) 组的 OS 以及 LCRC 患者的 RFS (p<0.04) 呈负相关。CLM 数量与整个队列的 RFS (p<0.0001)、RCRC (p<0.02)、LCRC (p<0.0001) 和 RC (p<0.02) 呈负相关。射频消融和联合手术导致整个队列的 OS 较差(p<0.03),整个队列的 RFS 较差(p<0.0003)和 LCRC 的患者(p<0.03)。原发结直肠癌手术和 CLM 手术之间较短的时间间隔可能导致来自 RCRC (p<0.05)、LCRC (p<0.05) 和 RC (p<0.02) 的 CLM 患者的 OS 和 RFS 较差。结论:原发肿瘤位置和临床危险因素对手术 CLM 的长期结果很重要。整个队列 (p<0.0003) 和 LCRC 患者 (p<0.03) 的 RFS 更差。原发结直肠癌手术和 CLM 手术之间较短的时间间隔可能导致来自 RCRC (p<0.05)、LCRC (p<0.05) 和 RC (p<0.02) 的 CLM 患者的 OS 和 RFS 较差。结论:原发肿瘤位置和临床危险因素对手术 CLM 的长期结果很重要。整个队列 (p<0.0003) 和 LCRC 患者 (p<0.03) 的 RFS 更差。原发结直肠癌手术和 CLM 手术之间较短的时间间隔可能导致来自 RCRC (p<0.05)、LCRC (p<0.05) 和 RC (p<0.02) 的 CLM 患者的 OS 和 RFS 较差。结论:原发肿瘤位置和临床危险因素对手术 CLM 的长期结果很重要。
更新日期:2020-01-01
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