Present study was planned to investigate the ameliorative effect of silver nanoparticles (AgNPs) on acetaminophen-induced nephrotoxicity. Our results demonstrate that therapy of AgNPs at three different doses (50, 100 and 150 μg/kg once only) prevented the acetaminophen (2 g/kg once only) induced acute renal toxicity. AgNPs treated animals also show less intensity in the histological alterations in kidneys and corroborating the results of analysis of serum urea and creatinine. In addition, AgNPs therapy prevented the acetaminophen-induced oxidative stress, which was confirmed by the alleviated lipid peroxidation, enhanced renal reduced glutathione content and restored enzymatic activities of superoxide dismutase, catalase and adenosine triphosphatase in kidney. Thus, our results demonstrate a possible protective potential of AgNPs on renal toxicity induced by acetaminophen. This study will definitely lead to the development of therapeutic drug against nephrotoxicity, after further clinical and preclinical studies.

中文翻译：

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对乙酰氨基酚引起的肾脏毒性：银纳米颗粒的预防作用。

本研究计划调查银纳米颗粒（AgNPs）对乙酰氨基酚引起的肾毒性的改善作用。我们的结果表明，以三种不同剂量（仅一次50、100和150μg/ kg）治疗AgNPs可以防止对乙酰氨基酚（一次仅2 g / kg）引起的急性肾毒性。用AgNPs处理的动物在肾脏的组织学改变中也表现出较低的强度，从而证实了血清尿素和肌酐的分析结果。此外，AgNPs疗法预防了对乙酰氨基酚引起的氧化应激，这可以通过减轻脂质过氧化作用，增强肾脏降低的谷胱甘肽含量和恢复肾脏中超氧化物歧化酶，过氧化氢酶和腺苷三磷酸酶的酶活性来证实。从而，我们的结果证明了AgNPs对乙酰氨基酚引起的肾脏毒性的潜在保护潜力。经过进一步的临床和临床前研究，这项研究必将导致抗肾毒性治疗药物的开发。