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Physiology of guanosine-based second messenger signaling in Bacillus subtilis
Biological Chemistry ( IF 3.7 ) Pub Date : 2020-11-26 , DOI: 10.1515/hsz-2020-0241
Gert Bange 1 , Patricia Bedrunka 1
Affiliation  

Abstract The guanosine-based second messengers (p)ppGpp and c-di-GMP are key players of the physiological regulation of the Gram-positive model organism Bacillus subtilis. Their regulatory spectrum ranges from key metabolic processes over motility to biofilm formation. Here we review our mechanistic knowledge on their synthesis and degradation in response to environmental and stress signals as well as what is known on their cellular effectors and targets. Moreover, we discuss open questions and our gaps in knowledge on these two important second messengers.

中文翻译:

枯草芽孢杆菌中基于鸟苷的第二信使信号的生理学

摘要 基于鸟苷的第二信使 (p)ppGpp 和 c-di-GMP 是革兰氏阳性模式生物枯草芽孢杆菌生理调节的关键参与者。它们的调节范围从关键代谢过程到运动性到生物膜形成。在这里,我们回顾了我们对它们响应环境和压力信号的合成和降解的机械知识,以及对它们的细胞效应器和靶标的了解。此外,我们讨论了关于这两个重要的第二信使的开放性问题和我们的知识差距。
更新日期:2020-11-26
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