Abstract

By using a mixed-ligand approach, a new Cu(II)-based coordination polymer (CP) with the chemical formula of {[Cu(tci)(bpy)(NO₃)·DMF·0.5CH₃CN}_n (H₃tci = tri(2-carboxyethyl) isocyanurate, bpy = 4,4-bipyridine), (1) was synthesized from a mixture of tri(2-carboxyethyl) isocyanurate, 4,4-bipyridine and Cu(NO₃)₂·3H₂O under solvothermal conditions. Furthermore, the anti-liver cancer activity of the compound was further evaluated. Then reactive oxygen species (ROS) accumulation in the cancer cells after compound treatment was evaluated. In addition to this, the relative expression of the ROS related genes was also determined with real time reverse transcription-polymerase chain reaction (RT-PCR).

摘要

通过使用混合配体方法，一种新的基于 Cu(II) 的配位聚合物 (CP)，其化学式为 {[Cu(tci)(bpy)(NO ₃ )·DMF·0.5CH ₃ CN} _n (H ₃ TCI =三（2-羧乙基）异氰脲酸酯，联吡啶= 4,4-联吡啶），（1）从三的混合物合成（2-羧乙基）异氰脲酸酯，4,4-联吡啶和Cu（NO ₃）₂ · 3 小时₂O 在溶剂热条件下。此外，进一步评估了该化合物的抗肝癌活性。然后评估化合物处理后癌细胞中活性氧 (ROS) 的积累。除此之外，还通过实时逆转录聚合酶链反应 (RT-PCR) 确定了 ROS 相关基因的相对表达。