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Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase
Cell Adhesion & Migration ( IF 3.2 ) Pub Date : 2020-09-03
Zhao Wang, Zhiqi Wang, Yusheng Pang, Huili Tong, Yunqin Yan, Shuang Li, Shufeng Li

FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with integrin β1 (ITGβ1). FAK, mediated by ITGβ1, regulates cell migration. Our results found FNDC4 to influence the expression of p-FAK, p-paxillin, and vinculin. Then, overexpressed or added FNDC4 protein could not influence migration and differentiation any more when the activated form of FAK was reduced. Therefore, we concluded that FNDC4 promotes the differentiation and migration of bovine MDSCs via the FAK, mediated by the ITGβ1 receptor.



中文翻译:

含有纤连蛋白III型结构域的4通过粘着斑激酶促进牛骨骼肌衍生卫星细胞的迁移和分化

FNDC4是一种抗炎因子,可改变巨噬细胞的激活状态。它用于治疗小鼠结肠炎。然而,其在肌肉形成和功能机制中的作用仍然未知。我们发现FNDC4促进牛MDSCs迁移和分化。此外,我们报道了它与整联蛋白β1(ITGβ1)相互作用。由ITGβ1介导的FAK调节细胞迁移。我们的结果发现FNDC4影响p-FAK,p-paxillin和vinculin的表达。然后,当FAK的活化形式减少时,过表达或添加的FNDC4蛋白不再影响迁移和分化。因此,我们得出结论,FNDC4通过由ITGβ1受体介导的FAK促进牛MDSC的分化和迁移。

更新日期:2020-09-03
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