Abstract

Background

Metabolic syndrome (MetS) in men is a common problem. Several studies highlight that testosterone deficiency is associated with metabolic disorders that may be explained by “myokines”. Irisin is an adipo-myokine that has beneficial metabolic effects.

Aim

To evaluate serum testosterone in a sample of Egyptian men with MetS diagnosed by NCEP ATP III, and correlate it with serum irisin level.

Methods

A total of 90 men (60 with MetS and 30 healthy age-matched controls) participated in the study. Testosterone level is estimated by an automated system, Irisin level was measured by ELISA.

Results

Circulating irisin was positively correlated with serum testosterone and was significantly lower in patients with MetS.

Conclusion

This study highlights the effect of serum testosterone on irisin formation from skeletal muscle. Recommendations; treatments of MetS may include testosterone supplementation. Further studies are needed to elucidate this association.

中文翻译：

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埃及代谢综合征男性样本中血清睾酮和鸢尾素水平的相关性；（病例对照研究）

摘要

背景

男性代谢综合征 (MetS) 是一个常见问题。几项研究强调，睾酮缺乏与代谢紊乱有关，这可以用“肌因子”来解释。鸢尾素是一种脂肪肌因子，具有有益的代谢作用。

目的

评估由 NCEP ATP III 诊断为 MetS 的埃及男性样本中的血清睾酮，并将其与血清鸢尾素水平相关联。

方法

共有 90 名男性（60 名患有代谢综合征和 30 名年龄匹配的健康对照组）参与了这项研究。睾酮水平由自动化系统估算，鸢尾素水平由 ELISA 测量。

结果

循环鸢尾素与血清睾酮呈正相关，并且在 MetS 患者中显着降低。

结论

这项研究强调了血清睾酮对骨骼肌中鸢尾素形成的影响。建议；MetS 的治疗可能包括补充睾酮。需要进一步的研究来阐明这种关联。