ABSTRACT

Introduction: In this review, we aim to highlight the impact of various processes and formulation variables influencing the characteristics of certain surfactant-based nanoconstructs for drug delivery.

Areas covered: The review includes the discussion on processing parameters for the preparation of nanoconstructs, especially those made up of surfactants. Articles published in last 15 years (437) were reviewed, 381 articles were selected for data review and most appropriate articles (215) were included in article. Effect of variables such as surfactant concentration and type, membrane additives, temperature, and pH-dependent transitions on morphology has been highlighted along with effect of shape on nanoparticle uptake by cells. Various characterization techniques explored for these nanostructures with respect to size, morphology, lamellarity, distribution, etc., and a separate section on polymeric vesicles and the influence of block copolymers, type of block copolymer, control of block length, interaction of multiple block copolymers on the structure of polymersomes and chimeric nanostructures have been discussed. Finally, applications, modification, degradation, and toxicological aspects of these drug delivery systems have been highlighted.

Expert opinion: Parameters influencing the morphology of micelles and vesicles can directly or indirectly affect the efficacy of small molecule cellular internalization as well as uptake in the case of biologicals.

摘要

简介：在这篇综述中，我们旨在强调各种过程和配方变量对某些基于表面活性剂的纳米结构药物递送特性的影响。

涵盖领域：审查包括对制备纳米结构，特别是那些由表面活性剂组成的工艺参数的讨论。审阅了过去15年中发表的文章（437），选择了381篇文章进行数据审阅，其中包括了最合适的文章（215）。诸如表面活性剂浓度和类型，膜添加剂，温度和pH依赖性转变之类的变量对形态的影响以及形状对细胞摄取纳米颗粒的影响都已得到强调。针对这些纳米结构的尺寸，形貌，层状性，分布等，探索了各种表征技术，并在聚合物囊泡和嵌段共聚物的影响上单独介绍了一部分，嵌段共聚物的类型，嵌段长度的控制，已经讨论了多嵌段共聚物对聚合物小体和嵌合纳米结构的相互作用。最后，这些药物递送系统的应用，修饰，降解和毒理学方面都得到了强调。

专家意见：影响胶束和囊泡形态的参数可以直接或间接影响小分子细胞内在化的功效以及生物制剂的摄取。