Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti‐cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti‐cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro‐senescent cancer.

中文翻译：

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细胞衰老与癌症：聚焦中药与天然产物

癌症是主要的死亡原因，也是严重威胁人类生命的主要公共卫生问题。在治疗癌症的各种方法中，中药和天然产物以其高效、副作用小的独特优势，具有突出的抗癌作用。细胞衰老是由应激引发的细胞生长停滞的生理过程，是抵御肿瘤发展的重要防线。近年来，中药和天然产物的活性成分作为一个有趣的研究热点，可以通过抑制端粒酶活性、引发DNA损伤、诱导SASP、激活或灭活癌基因等来诱导细胞衰老，从而抑制肿瘤的发生和发展。在本文中，