The misuse of antimicrobials is causing an alarming increase in the appearance of antibiotic‐resistant microorganisms. In this context, the identification of novel antibiotics against new targets and with low rates of resistance development is a major global challenge. In this article, we highlight a number of recent articles that exploit a variety of in vitro, in vivo and in silico state‐of‐the‐art approaches to identify and develop new antimicrobials. Rapid progress in this research field will be crucial to combating a global health problem, antimicrobial resistance, that is expected to be the leading cause of death by 2050.

中文翻译：

---

在抗药性时代挖掘新型抗生素。

滥用抗生素导致对抗生素耐药性微生物的出现惊人增加。在这种情况下，鉴定针对新靶标且耐药性发生率较低的新型抗生素是一项重大的全球挑战。在本文中，我们重点介绍了许多近期的文章，这些文章利用各种体外，体内和计算机模拟的最新方法来鉴定和开发新的抗菌素。该研究领域的快速进步对于应对全球健康问题-抗菌素耐药性至关重要，而抗菌素耐药性有望在2050年成为主要的死亡原因。