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Role of natural products in breast cancer related symptomology: Targeting chronic inflammation
Seminars in Cancer Biology ( IF 14.5 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.semcancer.2020.08.011
Kristina Andrijauskaite 1 , Michael J Wargovich 1
Affiliation  

Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the quality of life of cancer patients, but it could also influence their disease outcome. The magnitude of stress experienced by breast cancer patients is often compared to the post-traumatic stress disorder-like symptoms suggested to be mediated by the chronic inflammation including NF-κB, AKt, p53 and other inflammatory pathways. Here, we describe the symptomology of PTSD-like symptoms in breast cancer patients and argue that they may in fact be caused by or maintained through aspects of chronic inflammation mediated by the pro-inflammatory markers. Evidence exists that natural products that might attenuate or lessen the effects of chronic inflammation abound in the diet. We summarize some possible agents that might abate the genesis of symptoms experienced by breast cancer patients while mitigating the effect of inflammation.



中文翻译:

天然产物在乳腺癌相关症状中的作用:针对慢性炎症

乳腺癌是全世界女性中最常见的癌症。乳腺癌的治疗取得了许多进展,导致患有这种疾病的患者人数增加。越来越多的证据表明,癌症诊断和后果经历的压力不仅会影响癌症患者的生活质量,还会影响他们的疾病结果。乳腺癌患者所经历的压力程度通常与创伤后应激障碍样症状相比较,这些症状被认为是由包括 NF-κB、AKt、p53 和其他炎症途径在内的慢性炎症介导的。这里,我们描述了乳腺癌患者中 PTSD 样症状的症状学,并认为它们实际上可能是由促炎标志物介导的慢性炎症的某些方面引起或维持的。有证据表明,可以减轻或减轻慢性炎症影响的天然产品在饮食中比比皆是。我们总结了一些可能的药物,这些药物可能会减轻乳腺癌患者所经历的症状的发生,同时减轻炎症的影响。

更新日期:2020-09-03
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