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Retrieval of allocentric spatial memories is preserved up to thirty days and does not require higher brain metabolic demands.
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.nlm.2020.107312
Candela Zorzo 1 , Jorge L Arias 1 , Marta Méndez 1
Affiliation  

Spatial orientation is a cognitive ability that is indispensable for survival. Several visual distal cues present in the context can be integrated, establishing a cognitive map. Although there is cumulative evidence about the neural substrate involved in spatial memory acquisition, the brain networks mediating the processes involved in the retrieval of allocentric spatial memories have been studied less. Here, we aimed to explore the role of neuronal oxidative metabolism in the retrieval of allocentric spatial memories through cytochrome c oxidase (CCO) histochemistry seven, 15, 30, 45, and 60 days after task acquisition. Our behavioural results show that spatial memory retrieval in male and female rats is preserved seven, 15, and 30 days post-acquisition, but there is forgetfulness after this time, with subjects not being able to remember the position of the hidden platform after 45 and 60 dfearays. Regarding the study of male brain metabolism, we observed reduced CCO activity in the medial prefrontal cortex, the parietal, retrosplenial, rhinal cortex, and the hippocampal regions in all the groups that failed to solve the task. Similar results were found for female brain oxidative metabolism, in addition to certain differences between succefearssful-retrieval female groups. In conclusion, our work adds information about the behavioural retrieval of an allocentric spatial reference task, suggesting that recovering spatial information seven, 15, and 30days after acquisition is a simple task that does not require a high metabolic demand, in both male and female rats.



中文翻译:

检索异中心空间记忆最多可保存 30 天,并且不需要更高的大脑代谢需求。

空间定向是一种生存必不可少的认知能力。可以整合上下文中存在的几个视觉远端线索,建立认知地图。尽管有关于参与空间记忆获取的神经基质的累积证据,但对调节异中心空间记忆检索过程的大脑网络的研究较少。在这里,我们旨在探索神经元氧化代谢在通过细胞色素c检索异中心空间记忆中的作用。任务获得后 7、15、30、45 和 60 天的氧化酶 (CCO) 组织化学。我们的行为结果表明,雄性和雌性大鼠的空间记忆提取在获取后 7、15 和 30 天保留,但此后出现健忘,受试者在 45 天后无法记住隐藏平台的位置和60 天。关于男性大脑代谢的研究,我们观察到所有未能完成任务的组的内侧前额叶皮层、顶叶、脾后、鼻皮质和海马区的 CCO 活动降低。除了成功检索女性组之间的某些差异之外,还发现了女性大脑氧化代谢的类似结果。综上所述,

更新日期:2020-09-08
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