当前位置: X-MOL 学术Environ. Toxicol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Affinity of chlordecone and chlordecol for human serum lipoproteins.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.etap.2020.103486
Matthieu Delannoy 1 , Jean-Michel Girardet 2 , Fathia Djelti 1 , Frances T Yen 1 , Céline Cakir-Kiefer 1
Affiliation  

Chlordecone (CLD) is a chlorinated persistent organic pollutant (POP) whose presence despite the 1993 ban in agriculture areas has caused numerous public health concerns. CLD accumulates in the liver, and the CLD metabolite, chlordecol (CLD-OH) is found in bile, an important site of excretion for cholesterol transported to the liver via lipoproteins. Here, we studied the real-time molecular interaction between CLD and CLD-OH with human serum lipoproteins, LDL and HDL. While no interaction was detected between CLD and HDL, or between CLD-OH and LDL, relatively high specific affinities were observed between CLD and CLD-OH for LDL and HDL, respectively.



中文翻译:

十氯酮和十氯酚对人血清脂蛋白的亲和力。

十氯酮(CLD)是一种氯化的持久性有机污染物(POP),尽管在1993年禁止在农业地区中使用,但仍引起了许多公共卫生问题。CLD在肝脏中蓄积,胆汁中发现CLD代谢产物一氧化氯(CLD-OH),这是胆固醇通过脂蛋白转运至肝脏的重要排泄部位。在这里,我们研究了CLD和CLD-OH与人血清脂蛋白,LDL和HDL之间的实时分子相互作用。尽管在CLD和HDL之间或CLD-OH和LDL之间未检测到相互作用,但在CLD和CLD-OH之间分别观察到了相对较高的LDL和HDL比亲和力。

更新日期:2020-09-16
down
wechat
bug