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Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade.
Cell Stem Cell ( IF 23.9 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.stem.2020.08.008
Emmanuel Cazottes 1 , Claire Rougeulle 1
Affiliation  

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.



中文翻译:

直接到达X:通过FGF信号阻断在hESC中模拟人X染色体失活。

在本期《细胞干细胞》中,An等人。(2020)提供了一个模型来研究人类X染色体失活。他们追踪了X染色体的活性,并在幼稚的hESCS中追踪到细胞异质性,表明这是由于FGF信号传导的不完全阻断引起的,并且这样做时,分离出的细胞类似于植入前的成骨细胞。

更新日期:2020-09-03
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