An antibody's stability greatly influences its performance (i.e. its specificity and affinity). Thus, stability is a major issue for researchers and manufacturers, especially with the increasing use of antibodies in therapeutics, diagnostics and rapid analytical platforms. Here we review antibody stability under five headings: (i) measurement techniques; (ii) stability issues in expression and production (expression, proteolysis, aggregation); (iii) effects of antibody format and engineering on stability and (iv) formulation, drying and storage conditions. We consider more than 100 sources, including patents, and conclude with (v) recommendations to promote antibody stability.

抗体的稳定性极大地影响其性能（即其特异性和亲和力）。因此，对于研究人员和制造商而言，稳定性是一个主要问题，尤其是随着抗体在治疗，诊断和快速分析平台中的使用不断增加。在这里，我们从五个方面回顾了抗体的稳定性：（i）测量技术；（ii）表达和生产中的稳定性问题（表达，蛋白水解，聚集）；（iii）抗体形式和工程对稳定性的影响，以及（iv）制剂，干燥和储存条件。我们考虑了包括专利在内的100多种来源，并以（v）推荐以促进抗体稳定性为结论。