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Transforming growth factor beta signaling functions during mammalian kidney development.
Pediatric Nephrology ( IF 3 ) Pub Date : 2020-09-03 , DOI: 10.1007/s00467-020-04739-5
Mihai G Dumbrava 1 , Jon L Lacanlale 1, 2 , Christopher J Rowan 1 , Norman D Rosenblum 1, 2, 3, 4, 5
Affiliation  

Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development and how dysregulation of TGFβ signaling contributes to the pathogenesis of kidney malformation.



中文翻译:

在哺乳动物肾脏发育过程中转化生长因子 β 信号转导功能。

胚胎发生过程中的异常转化生长因子 β (TGFβ) 信号传导与严重的先天性异常有关,包括肾脏畸形。然而,与 TGFβ 信号相关的先天性肾脏畸形的分子机制仍然知之甚少。在这里,我们回顾了目前对 TGFβ 信号在肾脏发育过程中的谱系特异性作用的理解,以及 TGFβ 信号的失调如何导致肾脏畸形的发病机制。

更新日期:2020-09-03
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