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Human cytomegalovirus DNA detection in a recurrent glioblastoma multiforme tumour, but not in whole blood: a case report and discussion about the HCMV latency and therapy perspectives.
Journal of Neurovirology ( IF 3.2 ) Pub Date : 2020-09-03 , DOI: 10.1007/s13365-020-00901-9
Emiliya Nikolova 1, 2 , Petia Dimova 3 , Krasimir Minkin 4 , Tihomir Todorov 2 , Vanio Mitev 1 , Albena Todorova 1, 2
Affiliation  

In the current study, a 58-year-old male patient presented with recurrent glioblastoma multiforme (GBM). The patient underwent surgical resection, 4 months earlier, followed by radiotherapy and chemotherapy. During the second surgical intervention, tumour tissue and whole blood were sampled and analysed for human cytomegalovirus (HCMV) DNA, immediate early (IE) mRNA and pp65 mRNA. HCMV DNA was detected only in the recurrent tumour tissue but not in the whole blood. Neither IE mRNA nor pp65 mRNA was expressed. Our result suggests HCMV latency in the brain tumour with detectable level of viral DNA. More data are needed to understand the HCMV infection chronology in the brain tumours but our data could be important for further studies of HCMV antigens on the tumour surface and anti-GBM therapy.



中文翻译:

复发性多形性胶质母细胞瘤中的人巨细胞病毒 DNA 检测,但不是全血:病例报告和关于 HCMV 潜伏期和治疗前景的讨论。

在目前的研究中,一名 58 岁男性患者出现复发性多形性胶质母细胞瘤 (GBM)。该患者在 4 个月前接受了手术切除,随后进行了放疗和化疗。在第二次手术干预期间,对肿瘤组织和全血进行取样并分析人巨细胞病毒 (HCMV) DNA、即刻早期 (IE) mRNA 和 pp65 mRNA。仅在复发肿瘤组织中检测到 HCMV DNA,而在全血中未检测到。IE mRNA 和 pp65 mRNA 均未表达。我们的结果表明,具有可检测水平的病毒 DNA 的脑肿瘤中存在 HCMV 潜伏期。需要更多数据来了解脑肿瘤中 HCMV 感染的时序,但我们的数据对于进一步研究肿瘤表面的 HCMV 抗原和抗 GBM 治疗可能很重要。

更新日期:2020-09-03
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