当前位置: X-MOL 学术J. Neurovirol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Studying the neuropsychological sequelae of SARS-CoV-2: lessons learned from 35 years of neuroHIV research.
Journal of Neurovirology ( IF 3.2 ) Pub Date : 2020-09-03 , DOI: 10.1007/s13365-020-00897-2
Andrew Levine 1 , Ned Sacktor 2 , James T Becker 3
Affiliation  

The virology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the human immune response to the virus are under vigorous investigation. There are now several reports describing neurological symptoms in individuals who develop coronavirus disease 2019 (COVID-19), the syndrome associated with SARS-CoV-2 infection. The prevalence, incidence, and clinical course of these symptoms will become clearer in the coming months and years through epidemiological studies. However, the long-term neurological and cognitive consequence of SARS-CoV-2 infection will remain conjectural for some time and will likely require the creation of cohort studies that include uninfected individuals. Considering the early evidence for neurological involvement in COVID-19 it may prove helpful to compare SARS-CoV-2 with another endemic and neurovirulent virus, human immunodeficiency virus-1 (HIV-1), when designing such cohort studies and when making predictions about neuropsychological outcomes. In this paper, similarities and differences between SARS-CoV-2 and HIV-1 are reviewed, including routes of neuroinvasion, putative mechanisms of neurovirulence, and factors involved in possible long-term neuropsychological sequelae. Application of the knowledge gained from over three decades of neuroHIV research is discussed, with a focus on alerting researchers and clinicians to the challenges in determining the cause of neurocognitive deficits among long-term survivors.



中文翻译:

研究 SARS-CoV-2 的神经心理后遗症:从 35 年的 neuroHIV 研究中吸取的教训。

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的病毒学和人类对该病毒的免疫反应正在积极研究中。现在有几份报告描述了患有 2019 年冠状病毒病 (COVID-19) 的个体的神经系统症状,这是一种与 SARS-CoV-2 感染相关的综合征。通过流行病学研究,这些症状的患病率、发病率和临床过程将在未来数月和数年内变得更加清晰。然而,SARS-CoV-2 感染的长期神经和认知后果在一段时间内仍将是推测性的,并且可能需要开展包括未感染个体在内的队列研究。考虑到 COVID-19 神经系统受累的早期证据,将 SARS-CoV-2 与另一种地方性和神经毒性病毒进行比较可能会有所帮助,人类免疫缺陷病毒 1 (HIV-1),在设计此类队列研究和预测神经心理学结果时。本文综述了 SARS-CoV-2 和 HIV-1 之间的异同,包括神经侵袭途​​径、神经毒力的推定机制以及可能导致长期神经心理后遗症的因素。讨论了从超过 30 年的 neuroHIV 研究中获得的知识的应用,重点是提醒研究人员和临床医生注意确定长期幸存者神经认知缺陷原因的挑战。包括神经侵袭的途径、神经毒力的推定机制以及可能导致长期神经心理后遗症的因素。讨论了从超过 30 年的 neuroHIV 研究中获得的知识的应用,重点是提醒研究人员和临床医生注意确定长期幸存者神经认知缺陷原因的挑战。包括神经侵袭的途径、神经毒力的推定机制以及可能导致长期神经心理后遗症的因素。讨论了从超过 30 年的 neuroHIV 研究中获得的知识的应用,重点是提醒研究人员和临床医生注意确定长期幸存者神经认知缺陷原因的挑战。

更新日期:2020-09-03
down
wechat
bug